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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
10
Human Site:
S494
Identified Species:
22
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S494
Q
K
V
M
H
V
S
S
A
E
L
N
Y
S
L
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S494
Q
K
V
M
H
V
S
S
A
E
L
N
Y
S
L
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S494
Q
K
V
M
H
V
S
S
A
E
L
N
Y
S
L
Dog
Lupus familis
XP_540240
893
101055
S579
P
Q
K
A
M
H
V
S
S
A
E
L
N
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
V490
Y
S
L
R
E
L
Q
V
Q
R
V
A
H
V
S
Rat
Rattus norvegicus
NP_001099930
804
89584
V490
M
E
L
Q
A
Q
K
V
A
H
A
S
S
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
L484
Q
K
H
H
S
L
D
L
T
C
I
L
A
K
A
Chicken
Gallus gallus
XP_001235234
775
85980
K464
A
C
D
G
G
N
A
K
P
T
L
S
S
Q
S
Frog
Xenopus laevis
NP_001084841
660
74123
I349
V
E
D
V
K
E
E
I
L
Q
P
P
E
S
H
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
V259
R
I
S
E
D
F
N
V
F
Q
L
I
Q
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
G513
K
P
V
S
E
K
T
G
N
G
E
F
F
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
100
6.6
N.A.
0
6.6
N.A.
13.3
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
20
N.A.
26.6
26.6
N.A.
26.6
20
26.6
33.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
10
0
10
0
37
10
10
10
10
0
19
% A
% Cys:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
19
0
10
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
19
0
10
19
10
10
0
0
28
19
0
10
19
10
% E
% Phe:
0
0
0
0
0
10
0
0
10
0
0
10
10
0
0
% F
% Gly:
0
0
0
10
10
0
0
10
0
10
0
0
0
0
0
% G
% His:
0
0
10
10
28
10
0
0
0
10
0
0
10
0
10
% H
% Ile:
0
10
0
0
0
0
0
10
0
0
10
10
0
0
0
% I
% Lys:
10
37
10
0
10
10
10
10
0
0
0
0
0
19
0
% K
% Leu:
0
0
19
0
0
19
0
10
10
0
46
19
0
0
28
% L
% Met:
10
0
0
28
10
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
10
10
0
10
0
0
28
10
0
0
% N
% Pro:
10
10
0
0
0
0
0
0
10
0
10
10
0
0
0
% P
% Gln:
37
10
0
10
0
10
10
0
10
19
0
0
10
10
0
% Q
% Arg:
10
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% R
% Ser:
0
10
10
10
10
0
28
37
10
0
0
19
19
37
28
% S
% Thr:
0
0
0
0
0
0
10
0
10
10
0
0
0
0
0
% T
% Val:
10
0
37
10
0
28
10
28
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
28
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _